CONDITION OF THE BLOOD COAGULATION SYSTEM AND RISK OF VENOUS THROMBOSIS AND EMBOLISM IN ACUTE CALCULOUS CHOLECYSTITIS AND ITS COMPLICATIONS

Background. Acute calculous cholecystitis (ACC) is one of the most frequent causes urgent hospitalization in general surgical departments. It known that pathways inflammation and coagulation are closely related. The striking manifestation a violation hemostasis rheology under influence inflammatory process development hypercoagulation acute cholecystitis.
 Aim: determine condition blood system assessing risk venous thrombosis embolism (VTE) during treatment patients with its complications.
 Materials methods. design study was retrospective analysis results 206 complications Department surgery endoscopy Postgraduate education faculty, Lviv Danylo Halytsky national medical university (at Municipal non-profit enterprise "1st Territorial association Lviv", St. Panteleimon hospital) for period 2014-2018. Women predominated – 135 (65.5%). Age distribution ranged 18-90 (average 60.8±15.83). length stay hospital 1-41 days. Following forms ACC were: phlegmonous 86 (41,7%), gangrenous 115 (55,8%), perforated 5 (2,4%) patients.
 Results. Of entire cohort, cholecystomy performed 190 (92.2%) patients, which 129 (62.6%) underwent laparoscopic 61 (29.6%) conventional. Cholecystectomy lasted from 15 min to 1.5 hours duration 65±46.15 min). During laboratory examination complicated ACC, studied, presence normocoagulation detected 19.2% hypocoagulation 30.4% 50.4%. Examination hemostasiogram revealed following parameters: prothrombin time 17”, index 74.2%, fibrinogen 2.63 g/L; indicators: 6.5”, 130.2%, 6.5 g/L. VTE assessed by J. Caprini scale found vast majority (over 71.8%) have high very thromboembolic complications, namely: low 5.8%; average 12.6%; 45.2%; 36.4%.
 Conclusion. Hypercoagulation present 79.3% uncomplicated ACC. appearance leads 50.4% patients. Number an extremely according significantly exceeds (p<0,05) number without 52.2%. Inclusion test D-dimers protocol ultrasonographic scanning veins lower extremities will facilitate early detection, prevention VTE.